Erythropoietin: not just about erythropoiesis

Erythropoietin: not just about erythropoiesis.

Ghezzi, P; Bernaudin, M; Bianchi, R; Blomgren, K; Brines, M; Campana, W; Cavaletti, G; Cerami, A; Chopp, M; Coleman, T; Digicaylioglu, M; Ehrenreich, H; Erbayraktar, S; Erbayraktar, Z; Gassmann, M; Genc, S; Gokmen, N; Grasso, G; Juul, S; Lipton, S A; Hand, C C; Latini, R; Lauria, G; Leist, M; Newton, S S; Petit, E; Probert, L; Sfacteria, A; Siren, A L; Talan, M; Thiemermann, C; Westenbrink, D; ...

Erythropoietin is more than just a promoter of erythropoiesis.

The red cell production is continuously adjusted to cope with the loss of aged blood cells and to guarantee optimal oxygen supply to tissues and cells. Erythropoietin (EPO) is the critical growth factor that is produced either in the fetal liver or the adult kidney and acts on erythroid progenitor cells in the bone marrow to prevent them from undergoing programmed cell death. In turn, EPO produ...

Erythropoietin and Erythropoiesis in

T hat androgenic hormones stimulate erythropoiesis in animals and man has been known for many years.1’2 The principle mechanism for this activity probably results from an increased production of erythropoietin since both serum and urine levels are elevated by androgens.35 Even when plasma erythropoietin content is high, as in most anemias, further enhancement may occur after administration of t...

Erythropoietin, iron, and erythropoiesis.

Recent knowledge gained regarding the relationship between erythropoietin, iron, and erythropoiesis in patients with blood loss anemia, with or without recombinant human erythropoietin therapy, has implications for patient management. Under conditions of significant blood loss, erythropoietin therapy, or both, iron-restricted erythropoiesis is evident, even in the presence of storage iron and i...

Erythropoiesis, erythropoietin, and iron.